Yes, that's my experience from having one girl and one boy. Totally different. My daughter is a rule-follower who liked nothing more than quietly playing with her Duplo house. My son had to be taken out every morning to run off all his energy - a totally different experience. Girls tend to grow up to become women and boys tend to grow up to become men (though these days apparently that is not so certain...). And that's great. We want them to be different!